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Monitor Intently (one)berotralstat will improve the stage or effect of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Check or titrate substrate dose when berotralstat is coadministered with slim therapeutic index medicines which might be CYP3A substrates.
If methylene blue has to be administered, discontinue serotonergic drug right away and monitor for CNS toxicity. Serotonergic therapy may very well be resumed 24 hours soon after past methylene blue dose or right after 2 months of monitoring, whichever arrives 1st.
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nirmatrelvir/ritonavir will enhance the stage or effect of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
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Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for greater or diminished outcomes. CYP3A4 substrates may perhaps have to have dosage adjustment.
Contraindicated. Greater hazard of ergotism bringing about cerebral ischemia and/or ischemia with the extremitiesMinor (1)itraconazole increases levels of caffeine by reducing metabolism. Minor/Significance Unidentified.
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Stay clear of concomitant usage of tucatinib with CYP3A substrates, wherever small concentration modifications may produce critical or life-threatening toxicities. If unavoidable, lower CYP3A substrate dose In accordance with product labeling.
dasatinib will enhance the level or result of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.